2026-06-14T03:56:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/138232024-11-29T12:30:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988

00925njm 22002777a 4500 dc Martínez-Sanz, Javier author Jiménez, Daniel author Martínez-Campelo, Laura author Cruz, Raquel author Vizcarra, Pilar author Sánchez-Conde, Matilde author Ron, Raquel author Rodríguez, Mario author Herrera, Sabina author Moreno, Santiago author Lopez-Huertas, Maria Rosa author Serrano-Villar, Sergio author 2021-12 We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):493-496. 10.1080/22221751.2021.1902755 2222-1751 Emerging Microbes & Infections 33704002 http://hdl.handle.net/20.500.12105/13823 COVID-19 SARS-CoV-2 Genetic variants Single-nucleotide polymorphism Susceptibility Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers