2026-04-28T21:35:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/138042025-04-01T12:16:10Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Klingelhoefer, Lisa
author
Chaudhuri, Kallol Ray
author
Kamm, Christoph
author
Martínez-Martín, Pablo
author
Bhatia, Kailash
author
Sauerbier, Anna
author
Kaiser, Maximilian
author
Rodriguez-Blazquez, Carmen
author
Balint, Bettina
author
Untucht, Robert
author
Hall, Lynsey J
author
Mildenstein, Lauritz
author
Wienecke, Miriam
author
Martino, Davide
author
Gregor, Olaf
author
Storch, Alexander
author
Reichmann, Heinz
2022-03-23T11:32:43Z
2022-03-23T11:32:43Z
2019-10
Ann Clin Transl Neurol. 2019 Oct;6(10):2054-2065.
http://hdl.handle.net/20.500.12105/13804
31560179
10.1002/acn3.50900
2328-9503
Annals of Clinical and Translational Neurology
Objetive: To develop and validate a novel 14-item self-completed questionnaire (in English and German) enquiring about the presence of non-motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter study. Methods: The Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest) covers seven domains including sleep, autonomic symptoms, fatigue, emotional well-being, stigma, activities of daily living, sensory symptoms. The feasibility and clinimetric attributes were analyzed. Results: Data from 194 patients with CD (65.6% female, mean age 58.96 ± 12.17 years, duration of disease 11.95 ± 9.40 years) and 102 age- and sex-matched healthy controls (66.7% female, mean age 55.67 ± 17.62 years) were collected from centres in Germany and the UK. The median total NMS score in CD patients was 5 (interquartile range 3-7), significantly higher than in healthy controls with 1 (interquartile range 0.75-2.25) (P < 0.001, Mann-Whitney U-test). Evidence for intercorrelation and convergent validity is shown by moderate to high correlations of total DNMSQuest score with motor symptom severity (TWSTRS: rs = 0.61), clinical global impression (rs = 0.40), and health-related quality of life measures: CDQ-24 (rs = 0.74), EQ-5D index (rs = -0.59), and scale (rs = -0.49) (all P < 0.001). Data quality and acceptability was very satisfactory. Interpretation: The DNMSQuest, a patient self-completed questionnaire for NMS assessment in CD patients, appears robust, reproducible, and valid in clinical practice showing a tangible impact of NMS on quality of life in CD. As there is no specific, comprehensive, validated tool to assess the burden of NMS in dystonia, the DNMSQuest can bridge this gap and could easily be integrated into clinical practice.
eng
Validation of a self-completed Dystonia Non-Motor Symptoms Questionnaire
research article
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ValidationOfASelf_2019.pdf
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ValidationOfASelf_2019.pdf.txt