2026-06-14T03:54:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/137192024-09-27T08:00:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Font-Díaz, Joan
author
Jiménez-Panizo, Alba
author
Caelles, Carme
author
Vivanco, María dM
author
Pérez, Paloma
author
Aranda, Ana
author
Estébanez-Perpiñá, Eva
author
Castrillo, Antonio
author
Ricote, Mercedes
author
Valledor, Annabel F
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2022-03-03T12:13:41Z
2022-03-03T12:13:41Z
2021-08
Semin Cancer Biol . 2021 Aug;73:58-75
10.1016/j.semcancer.2020.12.007
1096-3650
1044-579X
Seminars in cancer biology
33309851
http://hdl.handle.net/20.500.12105/13719
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as biological sensors and use a combination of mechanisms to modulate positively and negatively gene expression in a spatial and temporal manner. The highly orchestrated biological actions of several NRs influence the proliferation, differentiation, and apoptosis of many different cell types. Synthetic ligands for several NRs have been the focus of extensive drug discovery efforts for cancer intervention. This review summarizes the roles in tumour growth and metastasis of several relevant NR family members, namely androgen receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR), thyroid hormone receptor (TR), retinoic acid receptors (RARs), retinoid X receptors (RXRs), peroxisome proliferator-activated receptors (PPARs), and liver X receptors (LXRs). These studies are key to develop improved therapeutic agents based on novel modes of action with reduced side effects and overcoming resistance.
eng
Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development.
journal article
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URL
https://repisalud.isciii.es/bitstreams/0e8bc0ca-8122-4a62-9761-d8911e9c6fff/download
File
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application/pdf
Nucl_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/4a1f5204-8de3-4300-a5ad-23fa906cf446/download
File
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Nucl_2021.pdf.txt