2026-06-14T03:54:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/137112024-09-27T07:57:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Paredes, Ana
author
Santos-Clemente, Rocio
author
Ricote, Mercedes
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Comunidad de Madrid (España)
2022-03-02T13:39:34Z
2022-03-02T13:39:34Z
2021-07-21
Int J Mol Sci . 2021 Jul 21;22(15):7775
10.3390/ijms22157775
1422-0067
International journal of molecular sciences
34360540
http://hdl.handle.net/20.500.12105/13711
The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. However, growing evidence suggests that the maintenance of cardiac function in health and disease depends on transcriptional and epigenetic regulation. Several studies have revealed that the complex transcriptional alterations underlying cardiovascular disease (CVD) manifestations such as myocardial infarction and hypertrophy is mediated by cardiac retinoid X receptors (RXR) and their partners. RXRs are members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors and drive essential biological processes such as ion handling, mitochondrial biogenesis, and glucose and lipid metabolism. RXRs are thus attractive molecular targets for the development of effective pharmacological strategies for CVD treatment and prevention. In this review, we summarize current knowledge of RXR partnership biology in cardiac homeostasis and disease, providing an up-to-date view of the molecular mechanisms and cellular pathways that sustain cardiomyocyte physiology.
eng
Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8153df8f-a293-4922-a317-a688c69f7d3c/download
File
MD5
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application/pdf
Unta_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/c9985f22-6268-4111-8645-009615dd9d9f/download
File
MD5
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text/plain
Unta_2021.pdf.txt