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                  <mods:namePart>Bermejo-Sanchez, Eva</mods:namePart>
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                  <mods:namePart>Cuevas Catalina, María Lourdes</mods:namePart>
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                  <mods:namePart>Mendioroz, J</mods:namePart>
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                  <mods:namePart>Martínez-Frías, María Luisa</mods:namePart>
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               <mods:identifier type="citation">Boletín del ECEMC: Rev Dismor Epidemiol 2003; V (nº 2): 60-100</mods:identifier>
               <mods:identifier type="issn">0210–3893</mods:identifier>
               <mods:identifier type="journal">Boletín del ECEMC: Revista de Dismorfología y Epidemiología</mods:identifier>
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               <mods:abstract>We have analysed data from the ECEMC database, gathered in the period 1980-2002, during which a total of 1,838,654 newborn infants were surveyed. The ECEMC programme covered 25.6% of total births occurred in Spain in 2001. We have calculated the global frequency of infants with congenital anomalies in different periods of time (before or after the passing of the law permitting voluntary interruption of gestation -VIG- following prenatal detection of anomalies). This allows to figure out the baseline frequency of congenital anomalies (corresponding to the period 1980-1985), and to assess the impact of VIG on the birth prevalence by comparing the baseline frequency of congenital anomalies with the frequency registered after 1985. The global frequency is decreasing over the years, and in 11 out of 17 Spanish Autonomic Regions we have also observed significant decreases of the frequency along the time. All those decreases are attributable to VIG. We have also studied the time distribution of the frequency of some selected anomalies, as well as their geographical distribution, and both are highly influenced by VIG. Nevertheless, the information on VIG is rather scarce. We consider that if it is not registered on a routine basis, it will be impossible to perform analytic studies on the causes of birth defects and to evaluate any preventive measure. Another question that will have to be approached in years to come is the distribution of birth defects depending on the country the parents come from, as immigration from other countries is increasing in Spain. Finally, we consider that even though the birth prevalence of these pathologies is decreasing as a consequence of the prenatal diagnosis and the possibility of voluntarily interrupting the gestation, it is necessary to search for primary prevention measures in order to get infants being born healthy.</mods:abstract>
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                  <mods:topic>Dismorfología</mods:topic>
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                  <mods:topic>Anomalías congénitas</mods:topic>
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                  <mods:topic>Epidemiología</mods:topic>
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                  <mods:title>Vigilancia Epidemiológica de Anomalías Congénitas en España en los últimos 23 años (periodo 1980-2001)</mods:title>
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