2026-06-14T03:53:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/134832025-05-09T16:46:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Garcia-Rios, Estefani
author
Nuévalos, Marcos
author
Mancebo, Francisco Jose
author
Perez-Romero, Pilar
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
2021-12-03T13:39:03Z
2021-12-03T13:39:03Z
2021-04-23
Front. Immunol. 2021 Apr 23;12:657144.
10.3389/fimmu.2021.657144
1664-3224
Frontiers In Immunology
33968058
http://hdl.handle.net/20.500.12105/13483
During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have an increased occurrence of CMV replication episodes and CMV-related complications. In this context, the use of adoptive transfer of CMV-specific T-cells has been widely investigated and applied to Hematopoietic Stem Cell Transplant patients and may be useful as a therapeutic alternative, to reconstitute the CMV specific T-cell response and to control CMV viremia in patients receiving a transplantation. However, only few authors have explored the use of T-cell adoptive transfer in SOT recipients. We propose a novel review in which we provide an overview of the impact of using CMV-specific T-cell adoptive transfer on the control of CMV infection in SOT recipients, the different approaches to stimulate, isolate and expand CMV-specific T-cells developed over the years and a discussion of the possible use of CMV adoptive cellular therapy in this SOT population. Given the timeliness and importance of this topic, we believe that such an analysis will provide important insights into CMV infection and its treatment/prevention.
eng
CMV treatment
CMV-specific immune response
T-cell adoptive transfer
Cellular therapy
Cytomegalovirus
Is It Feasible to Use CMV-Specific T-Cell Adoptive Transfer as Treatment Against Infection in SOT Recipients?
research article
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URL
https://repisalud.isciii.es/bitstreams/4225859b-0b00-40bb-8331-cc34a3b7e12a/download
File
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IsItFeasibleTo_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/ae87ff44-c3eb-488b-970d-0951b47a12bd/download
File
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text/plain
IsItFeasibleTo_2021.pdf.txt