2026-04-29T17:02:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/134442024-11-29T23:32:44Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Olmeda, David
author
Cerezo-Wallis, Daniela
author
Castellano-Sanz, Elena
author
García-Silva, Susana
author
Peinado Selgas, Hector
author
Soengas, MS
funder
Ministerio de Economía e Innovación (España)
funder
Melanoma Research Alliance
funder
Asociación Española Contra el Cáncer
funder
Worldwide Cancer Research
funder
Fundación Ramón Areces
funder
Instituto de Salud Carlos III
funder
Fundación BBVA
funder
Fundación La Caixa
funder
Cancer Research Institute Irvington Postdoctoral Fellowship
funder
Unión Europea. Comisión Europea
2021-10-19T10:07:15Z
2021-10-19T10:07:15Z
2021-08
Adv Drug Deliv Rev. 2021;175:113833.
10.1016/j.addr.2021.113833
1872-8294
Advanced drug delivery reviews
34147531
http://hdl.handle.net/20.500.12105/13444
Imaging of the lymphatic vasculature has gained great attention in various fields, not only because lymphatic vessels act as a key draining system in the body, but also for their implication in autoimmune diseases, organ transplant, inflammation and cancer. Thus, neolymphangiogenesis, or the generation of new lymphatics, is typically an early event in the development of multiple tumor types, particularly in aggressive ones such as malignant melanoma. Still, the understanding of how lymphatic endothelial cells get activated at distal (pre)metastatic niches and their impact on therapy is still unclear. Addressing these questions is of particular interest in the case of immune modulators, because endothelial cells may favor or halt inflammatory processes depending on the cellular context. Therefore, there is great interest in visualizing the lymphatic vasculature in vivo. Here, we review imaging tools and mouse models used to analyze the lymphatic vasculature during tumor progression. We also discuss therapeutic approaches based on nanomedicines to target the lymphatic system and the potential use of extracellular vesicles to track and target sentinel lymph nodes. Finally, we summarize main pre-clinical models developed to visualize the lymphatic vasculature in vivo, discussing their applications with a particular focus in metastatic melanoma.
eng
ENDOTHELIAL GROWTH-FACTOR
BREAST-CANCER PATIENTS
CELL-DERIVED EXOSOMES
PROX1 EXPRESSION
FACTOR-C
FLUORESCENCE MICROLYMPHOGRAPHY
TUMOR LYMPHANGIOGENESIS
ENHANCED PERMEABILIT
INDOCYANINE GREEN
DENDRITIC CELLS
Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles.
journal article
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