2026-06-30T01:54:34Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/134442024-11-29T23:32:44Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Olmeda, David author Cerezo-Wallis, Daniela author Castellano-Sanz, Elena author García-Silva, Susana author Peinado Selgas, Hector author Soengas, MS author 2021-08 Imaging of the lymphatic vasculature has gained great attention in various fields, not only because lymphatic vessels act as a key draining system in the body, but also for their implication in autoimmune diseases, organ transplant, inflammation and cancer. Thus, neolymphangiogenesis, or the generation of new lymphatics, is typically an early event in the development of multiple tumor types, particularly in aggressive ones such as malignant melanoma. Still, the understanding of how lymphatic endothelial cells get activated at distal (pre)metastatic niches and their impact on therapy is still unclear. Addressing these questions is of particular interest in the case of immune modulators, because endothelial cells may favor or halt inflammatory processes depending on the cellular context. Therefore, there is great interest in visualizing the lymphatic vasculature in vivo. Here, we review imaging tools and mouse models used to analyze the lymphatic vasculature during tumor progression. We also discuss therapeutic approaches based on nanomedicines to target the lymphatic system and the potential use of extracellular vesicles to track and target sentinel lymph nodes. Finally, we summarize main pre-clinical models developed to visualize the lymphatic vasculature in vivo, discussing their applications with a particular focus in metastatic melanoma. Adv Drug Deliv Rev. 2021;175:113833. 10.1016/j.addr.2021.113833 1872-8294 Advanced drug delivery reviews 34147531 http://hdl.handle.net/20.500.12105/13444 ENDOTHELIAL GROWTH-FACTOR BREAST-CANCER PATIENTS CELL-DERIVED EXOSOMES PROX1 EXPRESSION FACTOR-C FLUORESCENCE MICROLYMPHOGRAPHY TUMOR LYMPHANGIOGENESIS ENHANCED PERMEABILIT INDOCYANINE GREEN DENDRITIC CELLS Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles.