2026-05-17T05:52:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/134292024-11-28T16:17:09Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938

00925njm 22002777a 4500 dc Fuertes, Teresa author Salgado, Irene author de Yebenes, Virginia G author 2021-04 Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation. Front Immunol. 2021; 12:660450 10.3389/fimmu.2021.660450 1664-3224 Frontiers in immunology 33953721 http://hdl.handle.net/20.500.12105/13429 microRNA Fine-Tuning of the Germinal Center Response.