2026-06-14T02:29:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/134202024-11-29T10:52:40Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16980
Repisalud
author
Martin-Cofreces, Noa B.
author
Valpuesta, Jose Maria
author
Sanchez-Madrid, Francisco
funder
ALBA Synchrotron
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Fundación BBVA
funder
Fundación ProCNIC
funder
Instituto de Salud Carlos III
funder
Fundación La Caixa
2021-10-04T08:13:16Z
2021-10-04T08:13:16Z
2021-04-30
Front Cell Dev Biol. 2021; 9:658460
10.3389/fcell.2021.658460
2296-634X
Frontiers in cell and developmental biology
33912568
http://hdl.handle.net/20.500.12105/13420
Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that lead to the reorganization of the cytoskeleton and organelles and, eventually, activation of nuclear factors allowing transcription and ultimately, replication and cell division. Both the positioning of the lymphocyte centrosome in close proximity to the APC and the nucleation of a dense microtubule network beneath the plasma membrane from the centrosome support the T cell's intracellular polarity. Signaling from the TCR is facilitated by this traffic, which constitutes an important pathway for regulation of T cell activation. The coordinated enrichment upon T cell stimulation of the chaperonin CCT (chaperonin-containing tailless complex polypeptide 1; also termed TRiC) and tubulins at the centrosome area support polarized tubulin polymerization and T cell activation. The proteasome is also enriched in the centrosome of activated T cells, providing a mechanism to balance local protein synthesis and degradation. CCT assists the folding of proteins coming from de novo synthesis, therefore favoring mRNA translation. The functional role of this chaperonin in regulating cytoskeletal composition and dynamics at the immune synapse is discussed.
eng
Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton.
journal article
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FoldingfortheImmune_2021.pdf
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FoldingfortheImmune_2021.pdf.txt