2026-04-29T01:50:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133952024-09-27T08:47:37Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hernansanz-Agustin, Pablo
author
Enriquez, Jose Antonio
funder
Ministerio de Asuntos Económicos y Transformación Digital (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2021-09-15T12:33:51Z
2021-09-15T12:33:51Z
2021-03-09
Antioxidants (Basel). 2021; 10(3):415
2076-3921
http://hdl.handle.net/20.500.12105/13395
33803273
10.3390/antiox10030415
Antioxidants (Basel, Switzerland)
Reactive oxygen species (ROS) are series of chemical products originated from one or several electron reductions of oxygen. ROS are involved in physiology and disease and can also be both cause and consequence of many biological scenarios. Mitochondria are the main source of ROS in the cell and, particularly, the enzymes in the electron transport chain are the major contributors to this phenomenon. Here, we comprehensively review the modes by which ROS are produced by mitochondria at a molecular level of detail, discuss recent advances in the field involving signalling and disease, and the involvement of supercomplexes in these mechanisms. Given the importance of mitochondrial ROS, we also provide a schematic guide aimed to help in deciphering the mechanisms involved in their production in a variety of physiological and pathological settings.
eng
Generation of Reactive Oxygen Species by Mitochondria.
journal article
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URL
https://repisalud.isciii.es/bitstreams/d88f7d20-eb04-4183-8d57-e79a4a052ba3/download
File
MD5
cd0b4f9c023ef3a19164e3c5840233fc
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application/pdf
GenerationofReactiveOxygen_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/e3bf8c97-f71f-48d7-8325-ee44da63e56a/download
File
MD5
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text/plain
GenerationofReactiveOxygen_2021.pdf.txt