2026-05-20T03:47:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133892024-11-29T10:48:51Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_19604col_20.500.12105_16978col_20.500.12105_16984col_20.500.12105_19607
Repisalud
author
Casquero-Veiga, Marta
author
Bueno-Fernandez, Clara
author
Romero-Miguel, Diego
author
Lamanna-Rama, Nicolas
author
Nacher, Juan
author
Desco, Manuel
author
Soto-Montenegro, Maria Luisa
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Mapfre
funder
Fundación Alicia Koplowitz
funder
Fundación Tatiana Pérez de Guzmán el Bueno
funder
Comunidad de Madrid (España)
funder
Instituto de Investigación Sanitaria Gregorio Marañón
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Generalitat Valenciana (España)
2021-09-15T06:37:37Z
2021-09-15T06:37:37Z
2021-03-10
Sci Rep. 2021; 11(1):5580
10.1038/s41598-021-82987-7
2045-2322
Scientific reports
33692388
http://hdl.handle.net/20.500.12105/13389
Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being its effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major point of debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus (LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are able to modulate the activity of brain structures impaired in this pathology. Nevertheless, the long-term persistence of this modulation after DBS withdrawal was unexplored. Here we examine the in vivo presence of such changes 1 month after LH- and NAcc-DBS, along with differences in synaptic plasticity, following an exploratory approach. Thus, both stimulated and non-stimulated animals with electrodes in the NAcc showed a common pattern of brain metabolism modulation, presumably derived from the electrodes' presence. In contrast, animals stimulated in the LH showed a relative metabolic invariance, and a reduction of neuroplasticity molecules, evidencing long-lasting neural changes. Our findings suggest that the reversibility or persistence of DBS modulation in the long-term depends on the selected DBS target. Therefore, the DBS footprint would be influenced by the stability achieved in the neural network involved during the stimulation.
eng
Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity.
journal article
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