2026-06-14T00:41:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133792025-05-29T11:01:28Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Montaño, Karen J
author
Cuéllar, Carmen
author
Sotillo, Javier
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea
2021-09-13T10:01:10Z
2021-09-13T10:01:10Z
2021-04-22
Front Cell Infect Microbiol. 2021 Apr 22;11:639573.
10.3389/fcimb.2021.639573
2235-2988
Frontiers In Cellular And Infection Microbiology
33968800
http://hdl.handle.net/20.500.12105/13379
Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.
eng
Heligmosomoides polygyrus
Nippostrongylus brasiliensis
Trichuris muris
Host-parasite interactions
Immunomodulation
Proteomics
Soil-transmitted helminths (STHs)
Vaccines
Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.
research article
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URL
https://repisalud.isciii.es/bitstreams/7c065885-7c13-4fe2-930b-15218c5e0a1e/download
File
MD5
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application/pdf
RodentModelsForThe_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/b92b6089-eb14-44f4-8e53-a2e684502eb5/download
File
MD5
a673a55b79d1593b390db6d3ab26121d
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text/plain
RodentModelsForThe_2021.pdf.txt