2026-06-14T05:17:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133462024-09-27T08:55:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Mühleder, Severin
author
Fernandez-Chacon, Macarena
author
Garcia-Gonzalez, Irene
author
Benedito, Rui
funder
FWF Austrian Science Fund
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2021-09-02T08:51:12Z
2021-09-02T08:51:12Z
2021-02
Cell Mol Life Sci. 2021; 78(4):1329-54
10.1007/s00018-020-03664-y
1420-9071
Cellular and molecular life sciences : CMLS
33078209
http://hdl.handle.net/20.500.12105/13346
Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The general view is that an increase in vascular growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. However, several recent studies showed that an increase in mitogenic stimuli can also lead to the arrest of angiogenesis. This is due to the existence of intrinsic signaling feedback loops and cell cycle checkpoints that work in synchrony to maintain a balance between endothelial proliferation and sprouting. This balance is tightly and effectively regulated during tissue growth and is often deregulated or impaired in disease. Most therapeutic strategies used so far to promote vascular growth simply increase mitogenic stimuli, without taking into account its deleterious effects on this balance and on vascular cells. Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. We also discuss alternative approaches to increase the effectiveness of pro-angiogenic therapies in cardiovascular regenerative medicine.
eng
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology.
journal article
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URL
https://repisalud.isciii.es/bitstreams/bba41ccf-e043-4c6b-a2af-ba82f715d56d/download
File
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application/pdf
EndothelialSproutingProliferationOr_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/64574098-c0f7-46a2-98b0-a81a02d4cad2/download
File
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EndothelialSproutingProliferationOr_2021.pdf.txt