2026-05-20T03:47:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133452024-11-29T10:54:05Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16980col_20.500.12105_19607
Repisalud
author
Alcaraz-Serna, Ana
author
Bustos-Moran, Eugenio
author
Fernandez-Delgado, Irene
author
Calzada-Fraile, Diego
author
Torralba, Daniel
author
Marina-Zarate, Ester
author
Lorenzo-Vivas, Erika
author
Vazquez, Enrique
author
Barreto de Alburquerque, Juliana
author
Ruef, Nora
author
Gomez, Manuel J
author
Sanchez-Cabo, Fatima
author
Dopazo, Ana
author
Stein, Jens V
author
Ramiro, Almudena R
author
Sanchez-Madrid, Francisco
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Fundación BBVA
funder
Fundación La Caixa
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2021-09-02T08:39:55Z
2021-09-02T08:39:55Z
2021-02
Sci Adv. 2021; 7(6):eabb9965
10.1126/sciadv.abb9965
2375-2548
Science advances
33536205
http://hdl.handle.net/20.500.12105/13345
Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor Ccr7 as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.
eng
Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.
journal article
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ImmuneSynapseInstructsEpigenomic_2021.pdf
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ImmuneSynapseInstructsEpigenomic_2021_supp1.mp4
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ImmuneSynapseInstructsEpigenomic_2021_supp2.pdf
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ImmuneSynapseInstructsEpigenomic_2021.pdf.txt
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