2026-05-20T03:47:30Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/133452024-11-29T10:54:05Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16980col_20.500.12105_19607

00925njm 22002777a 4500 dc Alcaraz-Serna, Ana author Bustos-Moran, Eugenio author Fernandez-Delgado, Irene author Calzada-Fraile, Diego author Torralba, Daniel author Marina-Zarate, Ester author Lorenzo-Vivas, Erika author Vazquez, Enrique author Barreto de Alburquerque, Juliana author Ruef, Nora author Gomez, Manuel J author Sanchez-Cabo, Fatima author Dopazo, Ana author Stein, Jens V author Ramiro, Almudena R author Sanchez-Madrid, Francisco author 2021-02 Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor Ccr7 as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells. Sci Adv. 2021; 7(6):eabb9965 10.1126/sciadv.abb9965 2375-2548 Science advances 33536205 http://hdl.handle.net/20.500.12105/13345 Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.