2026-04-29T07:35:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/133182024-05-27T19:25:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Salobrar-García, Elena
author
López-Cuenca, Inés
author
Sánchez-Puebla, Lídia
author
de Hoz, Rosa
author
Fernández-Albarral, José A
author
Ramírez, Ana I
author
Bravo-Ferrer, Isabel
author
Medina, Violeta
author
Moro, Maria Angeles
author
Saido, Takaomi C
author
Saito, Takashi
author
Salazar, Juan J
author
Ramírez, José M
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Fondation Leducq
funder
Complutense University of Madrid (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2021-08-26T11:39:23Z
2021-08-26T11:39:23Z
2021-01-15
Front Aging Neurosci. 2021; 12:625642
1663-4365
http://hdl.handle.net/20.500.12105/13318
33542683
10.3389/fnagi.2020.625642
Frontiers in aging neuroscience
Background: Alzheimer's disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) to determine the total retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL-F/NL-F mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT) animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean total retinal thickness was analyzed following the Early Treatment Diabetic Retinopathy Study sectors. RNFL was measured in six sectors of axonal ring scans around the optic nerve. Results: In the APPNL-F/NL-F group compared to WT animals, the total retinal thickness changes observed were the following: (i) At 6-months-old, a significant thinning in the outer temporal sector was observed; (ii) at 15-months-old a significant thinning in the inner temporal and in the inner and outer inferior retinal sectors was noticed; (iii) at 17-months-old, a significant thickening in the inferior and nasal sectors was found in both inner and outer rings; and (iv) at 20-months-old, a significant thinning in the inner ring of nasal, temporal, and inferior retina and in the outer ring of superior and temporal retina was seen. In RNFL thickness, there was significant thinning in the global analysis and in nasal and inner-temporal sectors at 6 months old. Thinning was also found in the supero-temporal and nasal sectors and global value at 20 months old. Conclusions: In the APPNL-F/NL-F AD model, the retinal thickness showed thinning, possibly produced by neurodegeneration alternating with thickening caused by deposits and neuroinflammation in some areas of the retina. These changes over time are similar to those observed in the human retina and could be a biomarker for AD. The APPNL-F/NL-F AD model may help us better understand the different retinal changes during the progression of AD.
eng
Retinal Thickness Changes Over Time in a Murine AD Model APP NL-F/NL-F.
journal article
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