2026-05-22T01:41:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/132442024-09-27T08:16:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Leiva, Magdalena
author
Matesanz, Nuria
author
Pulgarin-Alfaro, Marta
author
Nikolic, Ivana
author
Sabio, Guadalupe
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación Lilly
funder
Unión Europea. Comisión Europea. H2020
funder
Unión Europea
funder
Fundación BBVA
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2021-07-15T11:21:27Z
2021-07-15T11:21:27Z
2020-12
Front Endocrinol (Lausanne). 2020; 11:572089
10.3389/fendo.2020.572089
1664-2392
Frontiers in endocrinology
33424765
http://hdl.handle.net/20.500.12105/13244
The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis. In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity. Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.
eng
Uncovering the Role of p38 Family Members in Adipose Tissue Physiology.
journal article
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URL
https://repisalud.isciii.es/bitstreams/c7798899-0486-45e2-bc42-36dda0d4483a/download
File
MD5
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application/pdf
UncoveringtheRoleof_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/5faaf8a5-ba12-4dc6-a871-93454478e1bf/download
File
MD5
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text/plain
UncoveringtheRoleof_2020.pdf.txt