2026-08-13T06:09:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/132252025-06-17T09:45:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Mutz, Cornelia N
author
Schwentner, Raphaela
author
Kauer, Maximilian O
author
Katschnig, Anna M
author
Kromp, Florian
author
Aryee, Dave N T
author
Erhardt, Sophie
author
Goiny, Michel
author
Alonso, Javier
author
Fuchs, Dietmar
author
Kovar, Heinrich
funder
FWF Austrian Science Fund
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Asociación Pablo Ugarte contra el cáncer infantil
funder
Asociación Infantil Oncológica de Madrid. La hucha de Tomás
funder
Fundación la Sonrisa de Alex para la investigación y el tratamiento del sarcoma de Ewing
funder
Instituto de Salud Carlos III
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Swedish Medical Research Council
funder
Miguelañez
2021-07-02T18:13:00Z
2021-07-02T18:13:00Z
2016
FEBS Lett. 2016 Jul;590(14):2063-75.
10.1002/1873-3468.12243
1873-3468
FEBS Letters
27282934
http://hdl.handle.net/20.500.12105/13225
Ewing sarcoma (ES) is an aggressive pediatric tumor driven by the fusion protein EWS-FLI1. We report that EWS-FLI1 suppresses TDO2-mediated tryptophan (TRP) breakdown in ES cells. Gene expression and metabolite analyses reveal an EWS-FLI1-dependent regulation of TRP metabolism. TRP consumption increased in the absence of EWS-FLI1, resulting in kynurenine and kynurenic acid accumulation, both aryl hydrocarbon receptor (AHR) ligands. Activated AHR binds to the promoter region of target genes. We demonstrate that EWS-FLI1 knockdown results in AHR nuclear translocation and activation. Our data suggest that EWS-FLI1 suppresses autocrine AHR signaling by inhibiting TDO2-catalyzed TRP breakdown.
eng
EWS-FLI1
Aryl hydrocarbon receptor
Tryptophan
EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
research article
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URL
https://repisalud.isciii.es/bitstreams/a60690d5-d860-48a0-9956-83c97879e460/download
File
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application/pdf
EWSFLI1ImpairsAryl_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/4237e629-d01e-4371-9826-1c883c9080c9/download
File
MD5
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text/plain
EWSFLI1ImpairsAryl_2016.pdf.txt