2026-08-05T15:45:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/132072024-09-27T09:01:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fernandez-Delgado, Irene
author
Calzada-Fraile, Diego
author
Sanchez-Madrid, Francisco
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Fundación BBVA
funder
Fundación La Marató TV3
funder
Fundación La Caixa
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Ministerio de Ciencia e Innovación (España)
2021-06-29T08:44:21Z
2021-06-29T08:44:21Z
2020-11-28
Cancers (Basel). 2020; 12(12):e3558
10.3390/cancers12123558
2072-6694
Cancers
33260499
http://hdl.handle.net/20.500.12105/13207
Extracellular vesicles (EVs) play a crucial role in intercellular communication as vehicles for the transport of membrane and cytosolic proteins, lipids, and nucleic acids including different RNAs. Dendritic cells (DCs)-derived EVs (DEVs), albeit variably, express major histocompatibility complex (MHC)-peptide complexes and co-stimulatory molecules on their surface that enable the interaction with other immune cells such as CD8+ T cells, and other ligands that stimulate natural killer (NK) cells, thereby instructing tumor rejection, and counteracting immune-suppressive tumor microenvironment. Malignant cells oppose this effect by secreting EVs bearing a variety of molecules that block DCs function. For instance, tumor-derived EVs (TDEVs) can impair myeloid cell differentiation resulting in myeloid-derived suppressor cells (MDSCs) generation. Hence, the unique composition of EVs makes them suitable candidates for the development of new cancer treatment approaches including prophylactic vaccine targeting oncogenic pathogens, cancer vaccines, and cancer immunotherapeutics. We offer a perspective from both cell sides, DCs, and tumor cells, on how EVs regulate the antitumor immune response, and how this translates into promising therapeutic options by reviewing the latest advancement in DEV-based cancer therapeutics.
eng
Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and Vaccines.
journal article
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URL
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File
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application/pdf
ImmuneRegulationbyDendritic_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/38cba39c-6fd5-44d6-8c27-9e2290eaf99c/download
File
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text/plain
ImmuneRegulationbyDendritic_2020.pdf.txt