2026-07-21T15:10:26Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/131392025-06-13T07:55:53Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Lozano, Encarnacion author de Lucas, Maria Pilar author Saez, Alberto G author 2016 The miR-58 family comprises 6 microRNAs with largely shared functions, and with an overall high expression, because one of its members, miR-58, is the most abundant microRNA in Caenorhabditis elegans. We recently found that 2 TGF-β signaling pathways, Sma/Mab and Dauer, responsible for body size and dauer formation respectively, among other phenotypes, are downregulated by the miR-58 family. Here, we further explore this family by showing that it also acts through the sta-1 3'UTR. sta-1 encodes a transcription factor, homologous to mammalian STATs, that inhibits dauer formation in association with the TGF-β Dauer pathway. We also observe that mutants with a constitutively active TGF-β Dauer pathway express higher levels of sta-1 mRNA. Our results reinforce the view of the miR-58 family and STA-1 as regulators of dauer formation in coordination with the TGF-β Dauer pathway. Worm. 2016 Sep 21;5(4):e1238560. 10.1080/21624054.2016.1238560 2162-4046 Worm 28090395 http://hdl.handle.net/20.500.12105/13139 Dauer TGF-β Dauer MicroRNAs Mir-58 Sta-1 sta-1 is repressed by mir-58 family in Caenorhabditis elegans