2026-07-21T11:53:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/130612025-04-24T11:04:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974
Repisalud
author
Rava, Marta
author
Domínguez-Domínguez, Lourdes
author
Bisbal, Otilia
author
López-Cortés, Luis Fernando
author
Busca, Carmen
author
Antela, Antonio
author
González-Ruano, Patricia
author
Hernández, Cristina
author
Iribarren, José Antonio
author
Rubio, Rafael
author
Moreno, Santiago
author
Jarrin Vera, Inmaculada
author
Cohort of the Spanish HIV/AIDS Research Network (CoRIS)
funder
Gilead Sciences (Spain)
2021-06-02T14:49:01Z
2021-06-02T14:49:01Z
2021-04
PLoS One. 2021;16(4):e0249864.
10.1371/journal.pone.0249864
1932-6203
PloS one
33882093
http://hdl.handle.net/20.500.12105/13061
Objectives: With the purpose of reducing the well-known negative impact of late presentation (LP) on people living with HIV (PLWH), guidelines on early HIV diagnosis were published in 2014 in Spain, but since then no data on LP prevalence have been published. To estimate prevalence and risk factors of LP and to evaluate their impact on the development of clinical outcomes in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) during 2004-2018. Methods: CoRIS is an open prospective multicenter cohort of PLWH, adults, naive to ART at entry. LP was defined as HIV diagnosis with CD4 count ≤350 cells/μL or an AIDS defining event (ADE). Multivariable Poisson regression models were used to estimate both prevalence ratios (PR) for the association of potential risk factors with LP and Incidence rate ratios (IRRs) for its impact on the development of the composite endpoint (first ADE, first serious non-AIDS event [SNAE] or overall mortality). Results: 14,876 individuals were included. Overall, LP prevalence in 2004-2018 was 44.6%. Risk factors for LP included older age, having been infected through injection drug use or heterosexual intercourse, low educational level and originating from non-European countries. LP was associated with an increased risk of the composite endpoint (IRR: 1.34; 95%CI 1.20, 1.50), ADE (1.39; 1.18, 1.64), SNAE (1.22; 1.01, 1.47) and mortality (1.71; 1.41, 2.08). Conclusions: LP remains a health problem in Spain, mainly among certain populations, and is associated with greater morbidity and mortality. Public policies should be implemented to expand screening and early diagnosis of HIV infection, for a focus on those at greatest risk of LP.
eng
Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018
research article
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