2026-06-14T06:44:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/130092025-04-04T13:47:09Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_19617
Repisalud
author
Rodríguez-Cobos, Javier
author
Viñal, David
author
Poves, Carmen
author
Fernández-Aceñero, María Jesús
author
Peinado Selgas, Hector
author
Pastor-Morate, Daniel
author
Prieto, Mª Isabel
author
Barderas Manchado, Rodrigo
author
Rodríguez-Salas, Nuria
author
Domínguez, Gemma
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2021-05-24T16:57:02Z
2021-05-24T16:57:02Z
2021-05
Cancers (Basel). 2021 May; 13(9): 2240.
10.3390/cancers13092240
2072-6694
Cancers
http://hdl.handle.net/20.500.12105/13009
The early diagnosis of colorectal cancer is a key factor in the overall survival of the patients. The actual screening programs include different approaches with significant limitations such as unspecificity, high invasiveness, and detection at late stages of the disease. The specific content of extracellular vesicles derived from malignant cells may represent a non-invasive technique for the early detection of colorectal cancer. Here, we studied the mRNA levels of ∆Np73, TAp73, and ∆133p53 in plasma-derived extracellular vesicles from healthy subjects (n = 29), individuals with premalignant lesions (n = 49), and colorectal cancer patients (n = 42). Extracellular vesicles’ ∆Np73 levels were already significantly high in subjects with premalignant lesions. ∆133p53 levels were statistically increased in colorectal cancer patients compared to the other two groups and were associated with patients’ survival. Remarkably, TAp73 mRNA was not detected in any of the individuals. The evaluation of ∆Np73, ∆133p53 and CEA sensitivity, specificity and AUC values supports ∆Np73 as a better early diagnosis biomarker and CEA as the best to identify advanced stages. Thus, low levels of CEA and a high content of ∆Np73 may identify in screening programs those individuals at higher risk of presenting a premalignant lesion. In addition, ∆133p53 emerges as a potential prognosis biomarker in colorectal cancer.
eng
ΔNp73
TAp73
Δ133p53
Colorectal cancer
Extracellular vesicles
Liquid biopsy
Screening programs
Biomarkers
Early diagnosis
Premalignant lesions
ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer
research article
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URL
https://repisalud.isciii.es/bitstreams/767da65f-f9b4-494e-bd71-b42ae6bd3f5a/download
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ΔNp73TAp73AndΔ133p53_2021.pdf
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https://repisalud.isciii.es/bitstreams/b745c796-12e9-4e6c-a940-a3e177aed27e/download
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ΔNp73TAp73AndΔ133p53Supplementary_2021.pdf
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https://repisalud.isciii.es/bitstreams/cc7e0181-59ed-4681-bc8d-401599456fbb/download
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ΔNp73TAp73AndΔ133p53_2021.pdf.txt
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https://repisalud.isciii.es/bitstreams/108b40a3-2b3d-4ac3-a0ed-0d019b049e14/download
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ΔNp73TAp73AndΔ133p53Supplementary_2021.pdf.txt