2026-06-14T03:33:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/130092025-04-04T13:47:09Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_19617

00925njm 22002777a 4500 dc Rodríguez-Cobos, Javier author Viñal, David author Poves, Carmen author Fernández-Aceñero, María Jesús author Peinado Selgas, Hector author Pastor-Morate, Daniel author Prieto, Mª Isabel author Barderas Manchado, Rodrigo author Rodríguez-Salas, Nuria author Domínguez, Gemma author 2021-05 The early diagnosis of colorectal cancer is a key factor in the overall survival of the patients. The actual screening programs include different approaches with significant limitations such as unspecificity, high invasiveness, and detection at late stages of the disease. The specific content of extracellular vesicles derived from malignant cells may represent a non-invasive technique for the early detection of colorectal cancer. Here, we studied the mRNA levels of ∆Np73, TAp73, and ∆133p53 in plasma-derived extracellular vesicles from healthy subjects (n = 29), individuals with premalignant lesions (n = 49), and colorectal cancer patients (n = 42). Extracellular vesicles’ ∆Np73 levels were already significantly high in subjects with premalignant lesions. ∆133p53 levels were statistically increased in colorectal cancer patients compared to the other two groups and were associated with patients’ survival. Remarkably, TAp73 mRNA was not detected in any of the individuals. The evaluation of ∆Np73, ∆133p53 and CEA sensitivity, specificity and AUC values supports ∆Np73 as a better early diagnosis biomarker and CEA as the best to identify advanced stages. Thus, low levels of CEA and a high content of ∆Np73 may identify in screening programs those individuals at higher risk of presenting a premalignant lesion. In addition, ∆133p53 emerges as a potential prognosis biomarker in colorectal cancer. Cancers (Basel). 2021 May; 13(9): 2240. 10.3390/cancers13092240 2072-6694 Cancers http://hdl.handle.net/20.500.12105/13009 ΔNp73 TAp73 Δ133p53 Colorectal cancer Extracellular vesicles Liquid biopsy Screening programs Biomarkers Early diagnosis Premalignant lesions ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer