2026-05-20T23:32:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/129922024-09-27T18:34:46Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Díez-Alonso, Manuel
author
Mendoza-Moreno, Fernando
author
Jiménez-Álvarez, Laura
author
Nuñez, Oscar
author
Blazquez-Martín, Alma
author
Sanchez-Gollarte, Ana
author
Matías-García, Belén
author
Molina, Raquel
author
San-Juan, Alberto
author
Gutierrez-Calvo, Alberto
2021-05-23T17:13:20Z
2021-05-23T17:13:20Z
2021-05
Mol Clin Oncol. 2021 May;14(5):93.
10.3892/mco.2021.2255
2049-9450
Molecular and Clinical Oncology
33767862
http://hdl.handle.net/20.500.12105/12992
The aim of the present study was to identify predictive parameters of survival in patients affected by stage IV colorectal cancer with synchronous and bilateral liver metastases. A retrospective cohort study was performed. Patients diagnosed between January 2013 and December 2018 were included in the present study. Data on the histopathological, clinical and treatment factors (chemotherapy as the first measure or resection of the primary tumor) were collected. The effect of each variable on survival was evaluated using Cox regression analysis. A total of 104 patients were included [43 women (41.3%) and 61 men (58.7%); mean age, 63 years]. The long-term survival rate at 36 months was 29% (median, 25 months). Kaplan-Meier analysis was used to estimate that survival was higher in patients with wild-type KRAS tumors (42%) than in patients with mutated KRAS tumors (9%; P=0.001). In the multivariate analysis, KRAS mutation (HR, 2.484; 95% CI, 1.472-4.192), T4 tumors (HR, 1.795; 95% CI, 1.045-3.084), resection/local treatment of hepatic metastases (HR, 0.447; 95% CI, 0.222-0.901), Eastern Cooperative Oncology Group performance status (HR, 1.632; 95% CI, 1.182-2.254), were revealed to have independent predictive value. The type of treatment (chemotherapy or resection of the primary tumor) did not influence the survival. The results indicated that mutation of the KRAS gene was an important prognostic factor and associated with survival.
eng
KRAS
Chemotherapy
Colorectal cancer
Hepatic metastasis
Survival
Prognostic factors of survival in stage IV colorectal cancer with synchronous liver metastasis: Negative effect of the KRAS mutation.
journal article
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PrognosticFactorsOfSurvival_2021.pdf
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https://repisalud.isciii.es/bitstreams/50d603d9-91a1-4a36-87b1-3258c1813acc/download
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PrognosticFactorsOfSurvival_2021.pdf.txt