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oai:repisalud.isciii.es:20.500.12105/129132024-09-27T20:24:13Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Salvador, Fernando author Lobo, Beatriz author Goterris, Lidia author Alonso-Cotoner, Carmen author Santos, Javier author Sulleiro, Elena author Bailo-Barroso, Begoña author Carmena, David author Sánchez-Montalvá, Adrián author Bosch-Nicolau, Pau author Espinosa-Pereiro, Juan author Fuentes Corripio, Isabel author Molina, Israel author 2021-04-19 The aim of the present study is to describe the occurrence of Blastocystis sp. detection among asymptomatic subjects and patients with irritable bowel syndrome in order to evaluate the potential association between irritable bowel syndrome and the parasitic infection. Cross-sectional study where adult patients with irritable bowel syndrome diagnosed according to Rome IV criteria were included. A control group was formed by asymptomatic subjects older than 18 years. Exclusion criteria were: immunosuppressive condition or having received any drug with demonstrated activity against Blastocystis sp. within the last 6 months before study inclusion. Epidemiological and clinical information was collected from all included participants. Two stool samples were obtained from all participants: one sample for microscopic examination and one sample for Blastocystis sp. PCR detection. Blastocystis sp. infection was defined by the positivity of any of the diagnostic techniques. Seventy-two participants were included (36 asymptomatic subjects and 36 patients with irritable bowel syndrome). Thirty-five (48.6%) were men, and median age of participants was 34 (IQR 29-49) years. The overall rate of Blastocystis sp. carriage was 27.8% (20/72). The prevalence assessed through microscopic examination was 22.2% (16/72), while the prevalence measured by PCR was 15.3% (11/72). When comparing the presence of Blastocystis sp. between asymptomatic subjects and IBS patients, we did not find any statistically significant difference (36.1% vs. 19.4% respectively, p = 0.114). regarding the occurrence of Blastocystis sp., no differences were found between asymptomatic participants and patients with irritable bowel disease irrespective of the diagnostic technique performed. Biology (Basel) . 2021 Apr 19;10(4):340. 2079-7737 http://hdl.handle.net/20.500.12105/12913 33921803 10.3390/biology10040340 Biology Blastocystis sp. Irritable Bowel Syndrome Pathogenesis Blastocystis sp. Carriage and Irritable Bowel Syndrome: Is the Association Already Established?