2026-04-29T00:59:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/128972024-09-27T09:15:46Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Robles-Vera, Iñaki
author
de la Visitación, Néstor
author
Sánchez, Manuel
author
Gómez-Guzmán, Manuel
author
Jiménez, Rosario
author
Moleón, Javier
author
González-Correa, Cristina
author
Romero, Miguel
author
Yang, Tao
author
Raizada, Mohan K
author
Toral, Marta
author
Duarte, Juan
funder
Ministerio de Economía y Competitividad (España)
funder
Regional Government of Andalusia (España)
funder
Unión Europea
funder
Instituto de Salud Carlos III
funder
NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2021-05-07T09:45:44Z
2021-05-07T09:45:44Z
2020-11-28
Antioxidants (Basel). 2020; 9(12):e1199
2076-3921
http://hdl.handle.net/20.500.12105/12897
33260593
10.3390/antiox9121199
Antioxidants (Basel, Switzerland)
Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether MMF improves dysbiosis in mineralocorticoid-induced hypertension. Male Wistar rats were assigned to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction, and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial community between CTR and DOCA groups was found, whereas the cluster belonging to DOCA-MMF group was found to be intermixed. No changes were found at the phylum level among all experimental groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This effect seems to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut associated with reduced brain neuroinflammation.
eng
Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats.
journal article
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