2026-04-29T07:21:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/128772025-05-26T14:55:35Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16982col_20.500.12105_19618
Repisalud
author
Cantón-Habas, Vanesa
author
Rich-Ruiz, Manuel
author
Moreno-Casbas, Teresa
author
Ramírez-Expósito, María Jesús
author
Martínez-Martos, Jose Manuel
author
Carrera-González, María Del Pilar
funder
Regional Government of Andalusia (España)
2021-05-05T12:24:37Z
2021-05-05T12:24:37Z
2021-04-01
J Clin Med . 2021 Apr 1;10(7):1424.
2077-0383
http://hdl.handle.net/20.500.12105/12877
33915996
10.3390/jcm10071424
Journal of Clinical Medicine
The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain.
eng
Biomarkers
Dementia
Nursing
Pain
Pain Assessment in Advanced Dementia (PAINAD)
Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
research article
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CorrelationBetweenBiomarkersOf_2021.pdf.txt