2026-04-29T07:21:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/128772025-05-26T14:55:35Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16982col_20.500.12105_19618

00925njm 22002777a 4500 dc Cantón-Habas, Vanesa author Rich-Ruiz, Manuel author Moreno-Casbas, Teresa author Ramírez-Expósito, María Jesús author Martínez-Martos, Jose Manuel author Carrera-González, María Del Pilar author 2021-04-01 The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain. J Clin Med . 2021 Apr 1;10(7):1424. 2077-0383 http://hdl.handle.net/20.500.12105/12877 33915996 10.3390/jcm10071424 Journal of Clinical Medicine Biomarkers Dementia Nursing Pain Pain Assessment in Advanced Dementia (PAINAD) Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate