2026-05-17T01:43:53Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/128502024-11-28T16:07:32Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
Ding, Qinglan
author
Spatz, Erica S
author
Lipska, Kasia J
author
Lin, Haiqun
author
Spertus, John A
author
Dreyer, Rachel P
author
Whittemore, Robin
author
Funk, Marjorie
author
Bueno, Hector
author
Krumholz, Harlan M
funder
NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
2021-05-04T07:23:20Z
2021-05-04T07:23:20Z
2021-04
Heart. 2021; 107:657-666
10.1136/heartjnl-2020-317101
1468-201X
1355-6037
Heart (British Cardiac Society)
33082173
http://hdl.handle.net/20.500.12105/12850
To examine prevalence and characteristics of newly diagnosed diabetes (NDD) in younger adults hospitalised with acute myocardial infarction (AMI) and investigate whether NDD is associated with health status and clinical outcomes over 12-month post-AMI.
In individuals (18-55 years) admitted with AMI, without established diabetes, we defined NDD as (1) baseline or 1-month HbA1c≥6.5%; (2) discharge diabetes diagnosis or (3) diabetes medication initiation within 1 month. We compared baseline characteristics of NDD, established diabetes and no diabetes, and their associations with baseline, 1-month and 12-month health status (angina-specific and non-disease specific), mortality and in-hospital complications.
Among 3501 patients in Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study, 14.5% met NDD criteria. Among 508 patients with NDD, 35 (6.9%) received discharge diagnosis, 91 (17.9%) received discharge diabetes education and 14 (2.8%) initiated pharmacological treatment within 1 month. NDD was more common in non-White (OR 1.58, 95% CI 1.23 to 2.03), obese (OR 1.72, 95% CI 1.39 to 2.12), financially stressed patients (OR 1.27, 95% CI 1.02 to 1.58). Compared with established diabetes, NDD was independently associated with better disease-specific health status and quality of life (p≤0.04). No significant differences were found in unadjusted in-hospital mortality and complications between NDD and established or no diabetes.
NDD was common among adults≤55 years admitted with AMI and was more frequent in non-White, obese, financially stressed individuals. Under 20% of patients with NDD received discharge diagnosis or initiated discharge diabetes education or pharmacological treatment within 1 month post-AMI. NDD was not associated with increased risk of worse short-term health status compared with risk noted for established diabetes.
NCT00597922.
eng
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults.
journal article
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