2026-06-30T03:03:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/127852025-04-22T11:41:23Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16958col_20.500.12105_16963col_20.500.12105_16970col_20.500.12105_16986col_20.500.12105_16990col_20.500.12105_19617
Repisalud
author
Moreno-Grau, Sonia
author
de Rojas, Itziar
author
Hernández, Isabel
author
Quintela, Inés
author
Montrreal, Laura
author
Alegret, Montserrat
author
Hernández-Olasagarre, Begoña
author
Madrid, Laura
author
González-Pérez, Antonio
author
Maroñas, Olalla
author
Rosende-Roca, Maitée
author
Mauleón, Ana
author
Vargas, Liliana
author
Lafuente, Asunción
author
Abdelnour, Carla
author
Rodríguez-Gómez, Octavio
author
Gil, Silvia
author
Santos-Santos, Miguel Ángel
author
Espinosa, Ana
author
Ortega, Gemma
author
Sanabria, Ángela
author
Pérez-Cordón, Alba
author
Cañabate, Pilar
author
Moreno, Mariola
author
Preckler, Silvia
author
Ruiz, Susana
author
Aguilera, Nuria
author
Pineda, Juan Antonio
author
Macías, Juan
author
Alarcón-Martín, Emilio
author
Sotolongo-Grau, Oscar
author
Marquié, Marta
author
Monté-Rubio, Gemma
author
Valero, Sergi
author
Benaque, Alba
author
Clarimón, Jordi
author
Bullido, María Jesús
author
Garcia-Ribas, Guillermo
author
Pástor, Pau
author
Sánchez-Juan, Pascual
author
Álvarez, Victoria
author
Piñol-Ripoll, Gerard
author
García-Alberca, Jose María
author
Royo, José Luis
author
Franco, Emilio
author
Mir, Pablo
author
Calero, Miguel
author
Medina, Miguel
author
Rábano, Alberto
author
Ávila, Jesús
author
Antúnez, Carmen
author
Real, Luis Miguel
author
Orellana, Adelina
author
Carracedo, Ángel
author
Sáez, María Eugenia
author
Tárraga, Lluís
author
Boada, Mercè
author
Ruiz, Agustín
funder
Fundación La Caixa
funder
Grifols (Spain)
funder
Fundació ACE
funder
Instituto de Salud Carlos III
funder
Ministerio de Sanidad (España)
funder
Unión Europea
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Regional Government of Andalusia (España)
funder
National Institutes of Health (Estados Unidos)
funder
United States Department of Defense
funder
NIH - National Institute on Aging (NIA) (Estados Unidos)
funder
NIH - National Institute of Biomedical Imaging and Bioengineering (NIBIB) (Estados Unidos)
funder
Innovative Medicines Initiative
funder
Unión Europea. Comisión Europea. 6 Programa Marco
funder
Alzheimer's Disease Genetics Consortium
2021-04-27T15:23:30Z
2021-04-27T15:23:30Z
2019
Moreno-Grau S, De Rojas I, Hernandez I, Quintela I, Montrreal L, Alegret M, et al. Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. Alzheimers Dement. 2019 Oct;15(10):1333-47.
10.1016/j.jalz.2019.06.4950
1552-5279
Alzheimer's & dementia : the journal of the Alzheimer's Association
http://hdl.handle.net/20.500.13003/17141
31473137
L2003282292
2-s2.0-85072869719
http://hdl.handle.net/20.500.12105/12785
490148500009
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series.
eng
Alzheimer's disease
Biological pathway
Cerebral amyloid angiopathy
GWAS
Vascular pathology
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GRaACE project.
research article
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GenomeWideAssociationAnalysis_2016.pdf
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GenomeWideAssociationAnalysis_2016.pdf.txt