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00925njm 22002777a 4500 dc Rubín-García, María author Vitelli-Storelli, Facundo author Molina, Antonio José author Zamora-Ros, Raúl author Aragones, Nuria author Adarnaz, Eva author Castaño-Vinyals, Gemma author Obón-Santacana, Mireia author Gómez-Acebo, Inés author Molina-Barceló, Ana author Fernández-Tardón, Guillermo author Jimenez-Moleon, Jose J. author Alguacil, Juan author Chirlaque, María-Dolores author Toledo, Estefanía author Perez-Gomez, Beatriz author Pollan-Santamaria, Marina author Kogevinas, Manolis author Martín, Vicente author 2020-10-26 Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results. Nutrients . 2020 Oct 26;12(11):3281. 10.3390/nu12113281 2072-6643 Nutrients 33114671 http://hdl.handle.net/20.500.12105/12751 MCC-Spain Anatomic Diet Epidemiology Gastric cancer Histologic Lignans Phenolic acids Polyphenols Stilbenes Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain