2026-06-14T03:42:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/127092024-11-29T23:15:15Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Masmudi-Martín, M
author
Zhu, L
author
Sanchez-Navarro, M
author
Priego, N
author
Casanova-Acebes, M
author
Giralt, E
author
Masmudi-Martín, M.
author
Zhu, L.
author
Sanchez-Navarro, M.
author
Priego, N.
author
Casanova-Acebes, M.
author
Ruiz-Rodado, V
author
Giralt, E.
author
Valiente, Manuel
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación La Marató TV3
funder
Bristol-Myers Squibb
funder
Fundación Ramón Areces
funder
Worldwide Cancer Research
funder
Unión Europea. Comisión Europea. H2020
funder
Cancer Research Institute (CRI). Clinic & Laboratory Integration Program (CLIP)
funder
Asociación Española Contra el Cáncer
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación La Caixa
funder
AstraZeneca
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2021-04-21T06:25:07Z
2021-04-21T06:25:07Z
2021-02
Adv Drug Deliv Rev.2021 Feb;169:79-99.
10.1016/j.addr.2020.12.002
1872-8294
0169-409X
Advanced drug delivery reviews
33321154
http://hdl.handle.net/20.500.12105/12709
Brain metastasis is emerging as a unique entity in oncology based on its particular biology and, consequently, the pharmacological approaches that should be considered. We discuss the current state of modelling this specific progression of cancer and how these experimental models have been used to test multiple pharmacologic strategies over the years. In spite of pre-clinical evidences demonstrating brain metastasis vulnerabilities, many clinical trials have excluded patients with brain metastasis. Fortunately, this trend is getting to an end given the increasing importance of secondary brain tumors in the clinic and a better knowledge of the underlying biology. We discuss emerging trends and unsolved issues that will shape how we will study experimental brain metastasis in the years to come.
eng
EXPERIMENTAL MODELS
PRECLINICAL THERAPY
BRAIN METASTASIS
ORGANOTROPISM
BBB
BTB
SMALL-MOLECULE DRUGS
NANOMEDICINES
IMMUNOTHERAPY
Brain metastasis models: What should we aim to achieve better treatments?
preprint
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Brainmetastasismodelswhat_2021.pdf
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text/plain
Brainmetastasismodelswhat_2021.pdf.txt