2026-08-29T19:28:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/126932024-11-30T00:59:02Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Boire, Adrienne
author
Brastianos, Priscilla K
author
Garzia, Livia
author
Valiente, Manuel
funder
Ministerio de Economía y Competitividad (España)
funder
Bristol-Myers Squibb
funder
Beug Foundation for Metastasis Research
funder
Fundación Ramón Areces
funder
Worldwide Cancer Research
funder
Unión Europea. Comisión Europea. H2020
funder
Cancer Research Institute (CRI). Clinic & Laboratory Integration Program (CLIP)
funder
Asociación Española Contra el Cáncer
funder
European Molecular Biology Organization
funder
Canadian Institutes of Health Research
funder
Terry Fox Research Institute
funder
Canadian Cancer Society Research Institute
funder
C17 Research Network
2021-04-20T08:29:29Z
2021-04-20T08:29:29Z
2020-01-20
Nat Rev Cancer.2020;20(1):4-11.
10.1038/s41568-019-0220-y
1474-1768
Nature reviews. Cancer
31780784
http://hdl.handle.net/20.500.12105/12693
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and melanoma, is associated with poor survival outcomes and poses distinct clinical challenges. The brain microenvironment, with its unique cell types, anatomical structures, metabolic constraints and immune environment, differs drastically from microenvironments of extracranial lesions, imposing a distinct and profound selective pressure on tumour cells that, in turn, shapes the metastatic process and therapeutic responses. Accordingly, the study of brain metastasis could uncover new therapeutic targets and identify novel treatment approaches to address the unmet clinical need. Moreover, such efforts could provide insight into the biology of primary brain tumours, which face similar challenges to brain metastases of extracranial origin, and vice versa. However, the paucity of robust preclinical models of brain metastasis has severely limited such investigations, underscoring the importance of developing improved experimental models that holistically encompass the metastatic cascade and/or brain microenvironment. In this Viewpoint, we asked four leading experts to provide their opinions on these important aspects of brain metastasis biology and management.
eng
Brain metastasis.
journal article
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