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00925njm 22002777a 4500 dc Grünewald, Thomas G P author Alonso, Marta author Avnet, Sofia author Banito, Ana author Burdach, Stefan author Cidre-Aranaz, Florencia author Di Pompo, Gemma author Distel, Martin author Dorado-Garcia, Heathcliff author Garcia-Castro, Javier author Gonzalez-Gonzalez, Laura author Grigoriadis, Agamemnon E author Kasan, Merve author Koelsche, Christian author Krumbholz, Manuela author Lecanda, Fernando author Lemma, Silvia author Longo, Dario L author Madrigal-Esquivel, Claudia author Morales-Molina, Alvaro author Musa, Julian author Ohmura, Shunya author Ory, Benjamin author Pereira-Silva, Miguel author Perut, Francesca author Rodriguez, Rene author Seeling, Carolin author Al Shaaili, Nada author Shaabani, Shabnam author Shiavone, Kristina author Sinha, Snehadri author Tomazou, Eleni M author Trautmann, Marcel author Vela, Maria author Versleijen-Jonkers, Yvonne M H author Visgauss, Julia author Zalacain, Marta author Schober, Sebastian J author Lissat, Andrej author English, William R author Baldini, Nicola author Heymann, Dominique author 2020 Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma. EMBO Mol Med . 2020 Nov 6;12(11):e11131. 10.15252/emmm.201911131 1757-4684 EMBO molecular medicine 33047515 http://hdl.handle.net/20.500.12105/12687 Bone sarcoma Molecular diagnostics Molecular medicine Soft tissue sarcoma Targeted therapy Sarcoma treatment in the era of molecular medicine.