2026-06-14T03:40:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/126802024-11-29T10:04:14Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16977col_20.500.12105_16982
Repisalud
author
Vázquez-Carballo, Cristina
author
Guerrero-Hue, Melania
author
García-Caballero, Cristina
author
Rayego-Mateos, Sandra
author
Opazo-Ríos, Lucas
author
Morgado-Pascual, José Luis
author
Herencia-Bellido, Carmen
author
Vallejo-Mudarra, Mercedes
author
Cortegano, Isabel
author
Gaspar, Maria Luisa
author
Andres, Belen de
author
Egido, Jesús
author
Moreno, Juan Antonio
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Sociedad Española de Cardiología
funder
Sociedad Española de Nefrología
funder
Sociedad Española de Arteriosclerosis
funder
University of Córdoba (España)
2021-04-16T16:49:50Z
2021-04-16T16:49:50Z
2021-01-15
Int J Mol Sci . 2021 Jan 15;22(2):816.
10.3390/ijms22020816
1422-0067
International journal of molecular sciences
33467524
http://hdl.handle.net/20.500.12105/12680
Acute kidney injury (AKI) is an important health problem, affecting 13.3 million individuals/year. It is associated with increased mortality, mainly in low- and middle-income countries, where renal replacement therapy is limited. Moreover, survivors show adverse long-term outcomes, including increased risk of developing recurrent AKI bouts, cardiovascular events, and chronic kidney disease. However, there are no specific treatments to decrease the adverse consequences of AKI. Epidemiological and preclinical studies show the pathological role of inflammation in AKI, not only at the acute phase but also in the progression to chronic kidney disease. Toll-like receptors (TLRs) are key regulators of the inflammatory response and have been associated to many cellular processes activated during AKI. For that reason, a number of anti-inflammatory agents targeting TLRs have been analyzed in preclinical studies to decrease renal damage during AKI. In this review, we updated recent knowledge about the role of TLRs, mainly TLR4, in the initiation and development of AKI as well as novel compounds targeting these molecules to diminish kidney injury associated to this pathological condition.
eng
Acute kidney injury
Drugs
Inflammation
Therapy
Toll-like receptors
Toll-Like Receptors in Acute Kidney Injury.
journal article
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TollLikeReceptorsIn_2021.pdf
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TollLikeReceptorsIn_2021.pdf.txt