2026-06-14T03:39:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/126792024-09-27T22:56:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Sempere, Julio
author
Llamosi, Mirella
author
Del Rio Menendez, Idoia
author
Lopez Ruiz, Beatriz
author
Domenech Lucas, Mirian
author
Gonzalez-Camacho, Fernando
funder
Ministerio de Economía, Industria y Competitividad (España)
2021-04-16T13:05:15Z
2021-04-16T13:05:15Z
2021-02-20
Vaccines (Basel). 2021 Feb 20;9(2):181.
10.3390/vaccines9020181
2076-393X
Vaccines
33672701
http://hdl.handle.net/20.500.12105/12679
Streptococcus pneumoniae is a pathogen responsible for millions of deaths worldwide. Currently, the available vaccines for the prevention of S. pneumoniae infections are the 23-valent pneumococcal polysaccharide-based vaccine (PPV-23) and the pneumococcal conjugate vaccines (PCV10 and PCV13). These vaccines only cover some pneumococcal serotypes (up to 100 different serotypes have been identified) and are unable to protect against non-vaccine serotypes and non-encapsulated pneumococci. The emergence of antibiotic-resistant non-vaccine serotypes after these vaccines is an increasing threat. Therefore, there is an urgent need to develop new pneumococcal vaccines which could cover a wide range of serotypes. One of the vaccines most characterized as a prophylactic alternative to current PPV-23 or PCVs is a vaccine based on pneumococcal protein antigens. The choline-binding proteins (CBP) are found in all pneumococcal strains, giving them the characteristic to be potential vaccine candidates as they may protect against different serotypes. In this review, we have focused the attention on different CBPs as vaccine candidates because they are involved in the pathogenesis process, confirming their immunogenicity and protection against pneumococcal infection. The review summarizes the major contribution of these proteins to virulence and reinforces the fact that antibodies elicited against many of them may block or interfere with their role in the infection process.
eng
Streptococcus pneumoniae
Choline-binding proteins
Pneumococcal vaccines
Protein vaccines
Pneumococcal Choline-Binding Proteins Involved in Virulence as Vaccine Candidates
journal article
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PneumococcalCholineBindingProteins_2021.pdf
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https://repisalud.isciii.es/bitstreams/e937727a-2459-4c9f-b1e8-860dfb5c5d45/download
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PneumococcalCholineBindingProteins_2021.pdf.txt