2026-06-14T03:31:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/126632025-06-13T10:14:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Villanueva, Andrea A author Sánchez-Gómez, Pilar author Muñoz-Palma, Ernesto author Puvogel, Sofía author Casas, Bárbara S author Arriagada, Cecilia author Peña-Villalobos, Isaac author Lois, Pablo author Ramírez Orellana, Manuel author Lubieniecki, Fabiana author Casco Claro, Fernando author Gallegos, Iván author Garcia-Castro, Javier author Torres, Vicente A author Palma, Verónica author 2021 Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK autophosphorylation and integrin β1 activation in a FAK dependent manner, thus promoting neuroblastoma cell migration. Moreover, Neogenin-1, which was detected in all tumor stages and was required for neuroblastoma cell migration, was found in a complex with integrin β1, FAK, and Netrin-1. Importantly, Neogenin-1 promoted neuroblastoma metastases in an immunodeficient mouse model. Taken together, these data show that Neogenin-1 is a metastasis-promoting protein that associates with FAK, activates integrin β1 and promotes neuroblastoma cell migration. Cell Adh Migr. 2021 Dec;15(1):58-73. 10.1080/19336918.2021.1892397 1933-6926 Cell adhesion & migration 33724150 http://hdl.handle.net/20.500.12105/12663 FAK Cell migration Neogenin-1 Netrin-1 Integrin-β1 activatio Metastasis Neuroblastoma The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation