2026-08-29T12:37:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/126032024-09-27T07:59:45Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Oda-Kawashima, Keiko author Sedukhina, Anna S author Okamoto, Naoki author Lytvyn, Mariya author Minagawa, Kimino author Iwata, Teppei author Kumai, Toshio author Sato, Eri author Inada, Eiichi author Yamaura, Ayako author Sakamoto, Miki author Roche-Molina, Marta author Bernal, Juan Antonio author Sato, Ko author 2020-01-03 Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sevoflurane (Sevo)] and intravenous [propofol (Prop)] anesthetics. Bioinformatics analysis revealed that nuclear factor-kappa B (NF-kB) signaling was inhibited by Sevo and promoted by Prop. Moreover, nuclear accumulation of p65 and transcription of NF-kB-regulated genes were suppressed in Sevo-administered mice, suggesting that Sevo inhibits the NF-kB signaling pathway. Our data demonstrate that NF-kB signaling is inhibited by Sevo and promoted by Prop. As NF-kB signaling plays an important role in myocardial remodeling, our results suggest that anesthetics may affect myocardial remodeling through NF-kB. FEBS Open Bio. 2020; 10(2):259-267 10.1002/2211-5463.12783 2211-5463 FEBS open bio 31898867 http://hdl.handle.net/20.500.12105/12603 anesthesia bioinformatics myocardialremodeling NF-kB propofol sevofluran NF-kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol.