2026-04-29T06:15:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/126012024-09-27T09:28:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Perez-Medina, Carlos
author
Teunissen, Abraham J P
author
Kluza, Ewelina
author
Mulder, Willem J M
author
van der Meel, Roy
funder
Dutch Research Council (Holanda)
funder
Comunidad de Madrid (España)
2021-04-12T07:22:26Z
2021-04-12T07:22:26Z
2020-07-30
Adv Drug Deliv Rev. 2020; 154-155:123-141
0169-409X
http://hdl.handle.net/20.500.12105/12601
32721459
10.1016/j.addr.2020.07.017
1872-8294
Advanced drug delivery reviews
Nanomedicine approaches can effectively modulate the biodistribution and bioavailability of therapeutic agents, improving their therapeutic index. However, despite the ever-increasing amount of literature reporting on preclinical nanomedicine, the number of nanotherapeutics receiving FDA approval remains relatively low. Several barriers exist that hamper the effective preclinical evaluation and clinical translation of nanotherapeutics. Key barriers include insufficient understanding of nanomedicines' in vivo behavior, inadequate translation from murine models to larger animals, and a lack of patient stratification strategies. Integrating quantitative non-invasive imaging techniques in nanomedicine development offers attractive possibilities to address these issues. Among the available imaging techniques, nuclear imaging by positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly attractive in this context owing to their quantitative nature and uncontested sensitivity. In basic and translational research, nuclear imaging techniques can provide critical quantitative information about pharmacokinetic parameters, biodistribution profiles or target site accumulation of nanocarriers and their associated payload. During clinical evaluation, nuclear imaging can be used to select patients amenable to nanomedicine treatment. Here, we review how nuclear imaging-based approaches are increasingly being integrated into nanomedicine development and discuss future developments that will accelerate their clinical translation.
eng
Nuclear imaging approaches facilitating nanomedicine translation.
journal article
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NuclearImagingApproachesFacilitating_2020.pdf
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NuclearImagingApproachesFacilitating_2020.pdf.txt