2026-06-14T03:39:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/125982024-09-27T23:31:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Vinuesa, Víctor
author
McConnell, Michael J
funder
Instituto de Salud Carlos III
2021-04-11T13:12:29Z
2021-04-11T13:12:29Z
2021-03-12
Int J Mol Sci . 2021 Mar 12;22(6):2876. d
10.3390/ijms22062876
1422-0067
International journal of molecular sciences
33809032
http://hdl.handle.net/20.500.12105/12598
Iron is essential for multiple bacterial processes and is thus required for host colonization and infection. The antimicrobial activity of multiple iron chelators and gallium-based therapies against different bacterial species has been characterized in preclinical studies. In this review, we provide a synthesis of studies characterizing the antimicrobial activity of the major classes of iron chelators (hydroxamates, aminocarboxylates and hydroxypyridinones) and gallium compounds. Special emphasis is placed on recent in-vitro and in-vivo studies with the novel iron chelator DIBI. Limitations associated with iron chelation and gallium-based therapies are presented, with emphasis on limitations of preclinical models, lack of understanding regarding mechanisms of action, and potential host toxicity. Collectively, these studies demonstrate potential for iron chelators and gallium to be used as antimicrobial agents, particularly in combination with existing antibiotics. Additional studies are needed in order to characterize the activity of these compounds under physiologic conditions and address potential limitations associated with their clinical use as antimicrobial agents.
eng
DIBI
Gallium
Iron acquisition
Iron chelators
Multidrug resistant bacteria
Synergy
Recent Advances in Iron Chelation and Gallium-Based Therapies for Antibiotic Resistant Bacterial Infections.
journal article
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RecentAdvancesInIron_2021.pdf
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RecentAdvancesInIron_2021.pdf.txt