2026-06-14T03:47:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/125942025-06-13T11:07:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
De la Vieja, Antonio
author
Riesco-Eizaguirre, Garcilaso
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Asociación Española Contra el Cáncer
funder
Instituto de Salud Carlos III
2021-04-09T20:34:40Z
2021-04-09T20:34:40Z
2021-02-27
Cancers (Basel) . 2021 Feb 27;13(5):995.
10.3390/cancers13050995
2072-6694
Cancers
33673669
http://hdl.handle.net/20.500.12105/12594
Thyroid radio-iodide therapy (RAI) is one of the oldest known and used targeted therapies. In thyroid cancer, it has been used for more than eight decades and is still being used to improve thyroid tumor treatment to eliminate remnants after thyroid surgery, and tumor metastases. Knowledge at the molecular level of the genes/proteins involved in the process has led to improvements in therapy, both from the point of view of when, how much, and how to use the therapy according to tumor type. The effectiveness of this therapy has spread into other types of targeted therapies, and this has made sodium/iodide symporter (NIS) one of the favorite theragnostic tools. Here we focus on describing the molecular mechanisms involved in radio-iodide therapy and how the alteration of these mechanisms in thyroid tumor progression affects the diagnosis and results of therapy in the clinic. We analyze basic questions when facing treatment, such as: (1) how the incorporation of radioiodine in normal, tumor, and metastatic thyroid cells occurs and how it is regulated; (2) the pros and cons of thyroid hormonal deprivation vs. recombinant human Thyroid Stimulating Hormone (rhTSH) in radioiodine residence time, treatment efficacy, thyroglobulin levels and organification, and its influence on diagnostic imaging tests and metastasis treatment; and (3) the effect of stunning and the possible causes. We discuss the possible incorporation of massive sequencing data into clinical practice, and we conclude with a socioeconomical and clinical vision of the above aspects.
eng
Radio-iodide treatment
Thyroid cancer
Sodium/iodide symporter (NIS)
Thyroid hormonal deprivation
Recombinant human TSH
Theragnostic
Stunning
Differentiated thyroid cancer
Radio-iodine-refractory thyroid cancer
Adjuvant therapy
Radio-Iodide Treatment: From Molecular Aspects to the Clinical View
research article
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URL
https://repisalud.isciii.es/bitstreams/302e3399-17c9-4545-9b87-ac21cf81fec0/download
File
MD5
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application/pdf
RadioLodideTreatmentFrom_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/2b2a1cbc-ac2d-4257-9325-ee8cc9d1c453/download
File
MD5
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text/plain
RadioLodideTreatmentFrom_2021.pdf.txt