2026-04-29T02:37:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/125862025-01-08T08:30:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Strauss, Ricardo A
author
Herrera-Leon, Laura
author
Guillén, Ana C
author
Castro, Julio S
author
Lorenz, Eva
author
Carvajal, Ana
author
Hernandez, Elizabeth
author
Navas, Trina
author
Vielma, Silvana
author
Lopez, Neiris
author
Lopez, Maria G
author
Aurenty, Lisbeth
author
Navas, Valeria
author
Rosas, Maria A
author
Drummond, Tatiana
author
Martínez, José G
author
Hernández, Erick
author
Bertuglia, Francis
author
Andrade, Omaira
author
Torres, Jaime
author
May, Jürgen
author
Herrera-León, Silvia
author
Eibach, Daniel
funder
Bernhard Nocht Institute for Tropical Medicine (Alemania)
2021-04-09T10:05:10Z
2021-04-09T10:05:10Z
2021-03-18
Sci Rep . 2021 Mar 18;11(1):6378.
http://hdl.handle.net/20.500.12105/12586
33737710
10.1038/s41598-021-85957-1
2045-2322
Scientific reports
In 2016, Venezuela faced a large diphtheria outbreak that extended until 2019. Nasopharyngeal or oropharyngeal samples were prospectively collected from 51 suspected cases and retrospective data from 348 clinical records was retrieved from 14 hospitals between November 2017 and November 2018. Confirmed pathogenic Corynebactrium isolates were biotyped. Multilocus Sequence Typing (MLST) was performed followed by next-generation-based core genome-MLST and minimum spanning trees were generated. Subjects between 10 and 19 years of age were mostly affected (n = 95; 27.3%). Case fatality rates (CFR) were higher in males (19.4%), as compared to females (15.8%). The highest CFR (31.1%) was observed among those under 5, followed by the 40 to 49 age-group (25.0%). Nine samples corresponded to C. diphtheriae and 1 to C. ulcerans. Two Sequencing Types (ST), ST174 and ST697 (the latter not previously described) were identified among the eight C. diphtheriae isolates from Carabobo state. Cg-MLST revealed only one cluster also from Carabobo. The Whole Genome Sequencing analysis revealed that the outbreak seemed to be caused by different strains with C. diphtheriae and C. ulcerans coexisting. The reemergence and length of this outbreak suggest vaccination coverage problems and an inadequate control strategy.
eng
Molecular and epidemiologic characterization of the diphtheria outbreak in Venezuela.
research article
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MolecularAndEpidemiologicCharacterization_2021.pdf
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https://repisalud.isciii.es/bitstreams/f9a3fc3d-a78b-4d5f-a6f0-61449a3a348d/download
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text/plain
MolecularAndEpidemiologicCharacterization_2021.pdf.txt