2026-06-14T03:54:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/125252025-05-30T16:32:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez-Perez, Maria
author
Sanchez-Tarjuelo, Rodrigo
author
Shor, Boris
author
Nistal-Villan, Estanislao
author
Ochando, Jordi
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Comisión Europea. H2020
2021-04-06T11:01:12Z
2021-04-06T11:01:12Z
2021
Front Immunol . 2021 Mar 8;12:632478
10.3389/fimmu.2021.632478
1664-3224
Frontiers in immunology
33763077
http://hdl.handle.net/20.500.12105/12525
Despite of the rapid development of the vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses and the proper infrastructure to vaccinate a good proportion of the world population. In this interim, the accessibility to the Bacille Calmette-Guerin (BCG) may mitigate the pandemic impact in some countries and the BCG vaccine offers significant advantages and flexibility in the way clinical vaccines are administered. BCG vaccination is a highly cost-effective intervention against tuberculosis (TB) and many low-and lower-middle-income countries would likely have the infrastructure, and health care personnel sufficiently familiar with the conventional TB vaccine to mount full-scale efforts to administer novel BCG-based vaccine for COVID-19. This suggests the potential for BCG to overcome future barriers to vaccine roll-out in the countries where health systems are fragile and where the effects of this new coronavirus could be catastrophic. Many studies have reported cross-protective effects of the BCG vaccine toward non-tuberculosis related diseases. Mechanistically, this cross-protective effect of the BCG vaccine can be explained, in part, by trained immunity, a recently discovered program of innate immune memory, which is characterized by non-permanent epigenetic reprogramming of macrophages that leads to increased inflammatory cytokine production and consequently potent immune responses. In this review, we summarize recent work highlighting the potential use of BCG for the treatment respiratory infectious diseases and ongoing SARS-CoV-2 clinical trials. In situations where no other specific prophylactic tools are available, the BCG vaccine could be used as a potential adjuvant, to decrease sickness of SARS-CoV-2 infection and/or to mitigate the effects of concurrent respiratory infections.
eng
Bacille Calmette-Guerin
SARS-CoV-2
Cross-protection
Trained immunity
Vaccination
The BCG Vaccine for COVID-19: First Verdict and Future Directions
research article
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TheBCGVaccineFor_2021.pdf
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TheBCGVaccineFor_2021.pdf.txt