2026-06-14T00:58:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/124772024-11-28T17:30:14Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16961col_20.500.12105_16978
Repisalud
author
Morales-Cano, Daniel
author
Barreira, Bianca
author
De Olaiz Navarro, Beatriz
author
Callejo, María
author
Mondejar-Parreño, Gema
author
Esquivel-Ruiz, Sergio
author
Lorente, Jose A.
author
Moreno, Laura
author
Barberá, Joan Albert
author
Cogolludo, Angel
author
Perez-Vizcaino, Francisco
funder
Ministerio de Asuntos Exteriores y Cooperación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Contra la Hipertensión Pulmonar
funder
Complutense University of Madrid (España)
funder
Ministerio de Educación (España)
2021-03-30T11:58:47Z
2021-03-30T11:58:47Z
2021-01
Antioxidants (Basel). 2021; 10(2):155
10.3390/antiox10020155
2076-3921
Antioxidants
33494520
http://hdl.handle.net/20.500.12105/12477
Current approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs. the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.
eng
Pulmonary hypertension
Vascular
Vasodilator
Oxygen-sensing
Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension
journal article
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