2026-06-14T03:51:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/124732024-09-27T10:10:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
López-Delgado, Alejandra C
author
Delgado, Irene
author
Cadenas, Vanessa
author
Sanchez-Cabo, Fatima
author
Torres, Miguel
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Fundación ProCNIC
funder
Ministerio de Economía y Competitividad (España)
2021-03-30T11:46:30Z
2021-03-30T11:46:30Z
2021-01-04
Development. 2021; 148(1):dev193813
10.1242/dev.193813
0950-1991
Development (Cambridge, England)
33298461
http://hdl.handle.net/20.500.12105/12473
Vertebrate axial skeletal patterning is controlled by co-linear expression of Hox genes and axial level-dependent activity of HOX protein combinations. MEIS transcription factors act as co-factors of HOX proteins and profusely bind to Hox complex DNA; however, their roles in mammalian axial patterning remain unknown. Retinoic acid (RA) is known to regulate axial skeletal element identity through the transcriptional activity of its receptors; however, whether this role is related to MEIS/HOX activity remains unknown. Here, we study the role of Meis in axial skeleton formation and its relationship to the RA pathway in mice. Meis elimination in the paraxial mesoderm produces anterior homeotic transformations and rib mis-patterning associated to alterations of the hypaxial myotome. Although Raldh2 and Meis positively regulate each other, Raldh2 elimination largely recapitulates the defects associated with Meis deficiency, and Meis overexpression rescues the axial skeletal defects in Raldh2 mutants. We propose a Meis-RA-positive feedback loop, the output of which is Meis levels, that is essential to establish anterior-posterior identities and patterning of the vertebrate axial skeleton.
eng
Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.
journal article
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URL
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AxialSkeletonAnteriorPosterior_2021.pdf
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AxialSkeletonAnteriorPosterior_2021.pdf.txt
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