2026-05-21T23:03:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/123902024-09-27T20:38:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Ochando, Jordi
author
Fayad, Zahi A
author
Madsen, Joren C
author
Netea, Mihai G
author
Mulder, Willem J M
funder
National Institutes of Health (Estados Unidos)
funder
Dutch Research Council (Holanda)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2021-03-22T16:28:12Z
2021-03-22T16:28:12Z
2020
Am J Transplant. 2020 Jan;20(1):10-18.
10.1111/ajt.15620
1600-6143
American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
31561273
http://hdl.handle.net/20.500.12105/12390
Consistent induction of donor-specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experimental treatments that target antigen-presentation (signal 1), costimulation (signal 2), and cytokine production (signal 3) to establish transplantation tolerance. While promising results have been obtained using therapeutic approaches that predominantly target the adaptive immune response, the long-term graft survival rates remain suboptimal. This suggests the existence of unrecognized allograft rejection mechanisms that contribute to organ failure. We postulate that trained immunity stimulatory pathways are critical to the immune response that mediates graft loss. Trained immunity is a recently discovered functional program of the innate immune system, which is characterized by nonpermanent epigenetic and metabolic reprogramming of macrophages. Since trained macrophages upregulate costimulatory molecules (signal 2) and produce pro-inflammatory cytokines (signal 3), they contribute to potent graft reactive immune responses and organ transplant rejection. In this review, we summarize the detrimental effects of trained immunity in the context of organ transplantation and describe pathways that induce macrophage training associated with graft rejection.
eng
Trained immunity in organ transplantation.
research article
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URL
https://repisalud.isciii.es/bitstreams/2b40b250-f9cf-4f1e-a769-b5a643b433ec/download
File
MD5
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application/pdf
TrainedImmunityInOrgan_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/44d9748f-25e0-4a1d-be3f-38324a47d32f/download
File
MD5
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text/plain
TrainedImmunityInOrgan_2020.pdf.txt