2026-06-14T03:51:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/122882025-04-01T12:30:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Dafsari, Haidar S
author
Chaudhuri, Kallol Ray
author
Ashkan, Keyoumars
author
Sachse, Lena
author
Mahlstedt, Picabo
author
Silverdale, Monty
author
Rizos, Alexandra
author
Strack, Marian
author
Jost, Stefanie T
author
Reker, Paul
author
Samuel, Michael
author
Visser-Vandewalle, Veerle
author
Evans, Julian
author
Antonini, Angelo
author
Martínez-Martín, Pablo
author
Timmermann, Lars
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
NIHR - Mental Health Biomedical Research Centre (Reino Unido)
funder
Dementia Unit at South London
funder
South London and Maudsley NHS Foundation Trust (Reino Unido)
funder
King College London
2021-03-16T12:00:28Z
2021-03-16T12:00:28Z
2020-06
J Neurol . 2020 Jun;267(6):1830-1841
10.1007/s00415-020-09743-1
1432-1459
Journal of neurology
32152689
http://hdl.handle.net/20.500.12105/12288
Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods: In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results: Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions: In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes.
eng
Deep brain stimulation
Non-motor symptoms
Parkinson’s disease sleep scale
Quality of life
Subthalamic nucleus
Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease
research article
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BeneficialEffectOf24_2020.pdf
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BeneficialEffectOf24_2020.pdf.txt