2026-06-14T02:22:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/122882025-04-01T12:30:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Dafsari, Haidar S author Chaudhuri, Kallol Ray author Ashkan, Keyoumars author Sachse, Lena author Mahlstedt, Picabo author Silverdale, Monty author Rizos, Alexandra author Strack, Marian author Jost, Stefanie T author Reker, Paul author Samuel, Michael author Visser-Vandewalle, Veerle author Evans, Julian author Antonini, Angelo author Martínez-Martín, Pablo author Timmermann, Lars author 2020-06 Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods: In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results: Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions: In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes. J Neurol . 2020 Jun;267(6):1830-1841 10.1007/s00415-020-09743-1 1432-1459 Journal of neurology 32152689 http://hdl.handle.net/20.500.12105/12288 Deep brain stimulation Non-motor symptoms Parkinson’s disease sleep scale Quality of life Subthalamic nucleus Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease