2026-04-29T07:24:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/121812024-11-29T18:48:33Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Escala-Garcia, Maria
author
Abraham, Jean
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Andrulis, Irene L
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Anton-Culver, Hoda
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Arndt, Volker
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Ashworth, Alan
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Auer, Paul L
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Auvinen, Päivi
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Beckmann, Matthias W
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Beesley, Jonathan
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Behrens, Sabine
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Benitez, Javier
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Bermisheva, Marina
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Blomqvist, Carl
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Blot, William
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Bogdanova, Natalia V
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Bojesen, Stig E
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Bolla, Manjeet K
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Børresen-Dale, Anne-Lise
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Brauch, Hiltrud
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Brenner, Hermann
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Brucker, Sara Y
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Burwinkel, Barbara
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Caldas, Carlos
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Canzian, Federico
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Chang-Claude, Jenny
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Chanock, Stephen J
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Chin, Suet-Feung
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Clarke, Christine L
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Couch, Fergus J
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Cox, Angela
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Cross, Simon S
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Czene, Kamila
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Daly, Mary B
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Dennis, Joe
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Devilee, Peter
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Dunn, Janet A
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Dunning, Alison M
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Dwek, Miriam
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Earl, Helena M
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Eccles, Diana M
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Eliassen, A Heather
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Ellberg, Carolina
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Evans, D Gareth
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Fasching, Peter A
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Figueroa, Jonine
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Flyger, Henrik
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Gago-Dominguez, Manuela
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Gapstur, Susan M
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García-Closas, Montserrat
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García-Sáenz, José A
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Gaudet, Mia M
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George, Angela
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Giles, Graham G
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Goldgar, David E
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González-Neira, Anna
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Grip, Mervi
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Guénel, Pascal
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Guo, Qi
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Haiman, Christopher A
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Håkansson, Niclas
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Hamann, Ute
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Harrington, Patricia A
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Hiller, Louise
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Hooning, Maartje J
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Hopper, John L
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Howell, Anthony
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Huang, Chiun-Sheng
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Huang, Guanmengqian
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Hunter, David J
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Jakubowska, Anna
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John, Esther M
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Kaaks, Rudolf
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Kapoor, Pooja Middha
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Keeman, Renske
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Kitahara, Cari M
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Kraft, Peter
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Lambrechts, Diether
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Le Marchand, Loic
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Lejbkowicz, Flavio
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Lindblom, Annika
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Lubiński, Jan
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Mannermaa, Arto
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Manoochehri, Mehdi
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Manoukian, Siranoush
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Margolin, Sara
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Martinez, Maria Elena
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Maurer, Tabea
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Mavroudis, Dimitrios
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Meindl, Alfons
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Milne, Roger L
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Mulligan, Anna Marie
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Neuhausen, Susan L
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Nevanlinna, Heli
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Newman, William G
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Olshan, Andrew F
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Olson, Janet E
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Olsson, Håkan
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Orr, Nick
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Peterlongo, Paolo
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Petridis, Christos
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Prentice, Ross L
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Presneau, Nadege
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Punie, Kevin
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Ramachandran, Dhanya
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Rennert, Gad
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Romero, Atocha
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Sachchithananthan, Mythily
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Saloustros, Emmanouil
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Sawyer, Elinor J
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Schmutzler, Rita K
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Schwentner, Lukas
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Scott, Christopher
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Simard, Jacques
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Sohn, Christof
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Southey, Melissa C
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Swerdlow, Anthony J
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Tamimi, Rulla M
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Tapper, William J
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Teixeira, Manuel R
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Terry, Mary Beth
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Thorne, Heather
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Tollenaar, Rob A E M
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Tomlinson, Ian
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Troester, Melissa A
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Truong, Thérèse
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Turnbull, Clare
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Vachon, Celine M
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van der Kolk, Lizet E
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Wang, Qin
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Winqvist, Robert
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Wolk, Alicja
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Yang, Xiaohong R
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Ziogas, Argyrios
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Pharoah, Paul D P
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Hall, Per
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Wessels, Lodewyk F A
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Chenevix-Trench, Georgia
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Bader, Gary D
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Dörk, Thilo
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Easton, Douglas F
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Canisius, Sander
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Schmidt, Marjanka K
author
Gonzalez Neira, Anna
author
Andrulis, Irene L.
author
Auer, Paul L.
author
Beckmann, Matthias W.
author
Bogdanova, Natalia V.
author
Bojesen, Stig E.
author
Bolla, Manjeet K.
author
Brucker, Sara Y.
author
Chanock, Stephen J.
author
Clarke, Christine L.
author
Couch, Fergus J.
author
Cross, Simon S.
author
Daly, Mary B.
author
Dunn, Janet A.
author
Dunning, Alison M.
author
Earl, Helena M.
author
Eccles, Diana M.
author
Eliassen, A. Heather
author
Evans, D. Gareth
author
Fasching, Peter A.
author
Gapstur, Susan M.
author
García-Sáenz, José A.
author
Gaudet, Mia M.
author
Giles, Graham G.
author
Goldgar, David E.
author
Haiman, Christopher A.
author
Harrington, Patricia A.
author
Hooning, Maartje J.
author
Hopper, John L.
author
Hunter, David J.
author
John, Esther M.
author
Kitahara, Cari M.
author
Koppert, Linetta B
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Kristensen, Vessela N
author
Milne, Roger L.
author
Neuhausen, Susan L.
author
Newman, William G.
author
Olshan, Andrew F.
author
Olson, Janet E.
author
Prentice, Ross L.
author
Sawyer, Elinor J.
author
Schmutzler, Rita K.
author
Southey, Melissa C.
author
Swerdlow, Anthony J.
author
Tamimi, Rulla M.
author
Tapper, William J.
author
Tollenaar, Rob A. E. M.
author
Troester, Melissa A.
author
Vachon, Celine M.
author
van der Kolk, Lizet E.
author
Yang, Xiaohong R.
author
Pharoah, Paul D. P.
author
Wessels, Lodewyk F. A.
author
Bader, Gary D.
author
Easton, Douglas F.
author
Schmidt, Marjanka K.
funder
National Institute for Health Research (Reino Unido)
funder
German Cancer Research Center
funder
United States Department of Health and Human Services
funder
Cancer Research UK (Reino Unido)
funder
Unión Europea. Comisión Europea
funder
Canadian Institutes of Health Research
funder
Ministere de l'Economie, Science et Innovation du Quebec (Canadá)
funder
Dutch Cancer Society (Holanda)
funder
Instituto de Salud Carlos III
funder
Asociación Española Contra el Cáncer
funder
Deutsche Krebshilfe
funder
Russian Foundation for Basic Research
funder
Swedish Research Council
funder
Breast Cancer Now (Reino Unido)
2021-03-10T09:16:20Z
2021-03-10T09:16:20Z
2020-11-01
Nat Commun.2020 ;11(1):312
http://hdl.handle.net/20.500.12105/12181
31949161
10.1038/s41467-019-14100-6
2041-1723
Nature communications
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
eng
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
journal article
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